Custom Peptides
Cayman Chemical RuxolItInIb 10mg
A potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5 nM, respectively; blocks IL-6 signaling (IC50 = 281 nM) and proliferation of JAK2V617F+ Ba/F3 cells (IC50 = 127 nM); reduces splenomegaly, decreases circulating levels of IL-6 and TNF-α, eliminates neoplastic cells, and prolongs survival in a mouse model of JAK2V617F+ MPN
Cayman Chemical LaHydroxyglutarIc AcIdod 10mg
An α-hydroxy acid; metabolized to α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase; levels are increased in 2-hydroxyglutaric aciduria; competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation
Cayman Chemical MItomycIn C 10mg
An antitumor antibiotic that crosslinks double stranded DNA and is widely used as a tool to selectively inhibit DNA synthesis and mutagenensis, to stimulate genetic recombination, chromosome breakage and sister chromatid exchange, and to induce DNA repair
Cayman Chemical TunIcamycIn MIxture 10mg
A mixture of tunicamycins with variable N-acyl fatty acid chain lengths; inhibitor of HexNAc phosphotransferases and peptidoglycan biosynthesis in bacteria; inhibitor of GPT and glycosylation in eukaryotes; sensitizes EGFR inhibitor-resistant U251 and Bx/PC3 cells to irradiation
Cayman Chemical 1-DeoxymnojIrImycInhydroc 10mg
A specific inhibitor of class I α-1,2-mannosidase (IC50 = 20 mM), a key enzyme for N-glycan processing in the endoplasmic reticulum and Golgi; inhibiting α-1,2-mannosidase with 1-Deoxymannojirimycin generates N-linked oligosaccharides with high mannose content, preventing proteasomal degradation of misfolded proteins
Cayman Chemical -Cloprostenol 10mg
A synthetic analog of PGF2α; an FP receptor agonist and a potent luteolytic agent in rats and hamsters; the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity
Cayman Chemical S-AdenosylhomocysteIn 10mg
An amino acid derivative and an intermediate, by-product, or modulator of several metabolic pathways, including the activated methyl cycle and cysteine biosynthesis; also a product of SAM-dependent methylation of biological molecules, including DNA, RNA, and histones, and other proteins
Cayman Chemical CL 316 243sodIum salt 10mg
A β3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over β1 and β2; causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity
Cayman Chemical Lamotrgn 10mg
An anticonvulsant; inhibits Nav1.2, Nav1.5, and Nav1.8 in HEK293 cells expressing the recombinant human channels (IC50s = 10, 62, and 96 μM, respectively); inhibits high voltage-activated calcium currents in isolated rat cortical neurons (IC50 = 12.3 µM), an effect that can be reversed by ω-conotoxin GVIA and ω-agatoxin IVA; protects against MES-induced seizures in mice and rats (ED50s = 10.1 and 7.4 µmol/kg, respectively); decreases mechanical allodynia in a rat model of neuropathic pain induced by spinal nerve ligation (ED50 = 47 µmol/kg)
Cayman Chemical Tenatoprazole 10mg
A proton pump inhibitor, blocking hog gastric H+/K+-ATPase activity with an IC50 value of 6.2 µM; blocks induced gastric acid secretion and ulcer formation in rats and humans
Cayman Chemical EmpaglIflozIn 10mg
An SGLT2 inhibitor (IC50 = 3.1 nM for the human transporter); reduces non-fasting blood glucose levels, as well as aortic superoxide levels and cardiac interstitial fibrosis, in db/db mice when administered in the diet at 0.03%; decreases the severity of glomerulosclerosis, as well as reduces the escape latency in the Morris water maze, in the same model
Cayman Chemical ZonIporIdehydrochlorIde 10mg
Selectively inhibits human NHE-1 with an IC50 value of 14 nM; reduces infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function
Cayman Chemical 1Naphthoyl2methylIndole 10mg
An analytical reference standard categorized as a precursor in the synthesis of synthetic cannabinoids; intended for research and forensic applications
Cayman Chemical AT7519hydrochlorIde 10mg
An ATP-competitive inhibitor of Cdk1, 2, 4, 5, 6, and 9 with IC50 values of 210, 47, 100, 13, 170, and 50s = 40-940 nM in vitro) and human tumor xenograft models, inhibiting cell cycle progression and inducing apoptosis
Cayman Chemical ahydroy Farnsyl phsphonIc 10mg
α-hydroxy Farnesyl phosphonic acid is a nonhydrolyzable analog of farnesyl pyrophosphate which acts as a competitive inhibitor of farnesyl transferase (FTase).{1199,5456} At concentrations greater than 1 µM, α-hydroxy farnesyl phosphonic acid inhibits the processing of Ras in Ha-ras-transformed NIH3T3 cells.{1196}